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KMID : 0356919930260020257
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Korean Journal of Anesthesiology
1993 Volume.26 No. 2 p.257 ~ p.265
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Clinical Effects of Propofol According to Dosage
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아태훈
조남수/유병식/임경준/정종달/김용일
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Abstract
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Propofol(Diprivan , England ICI) is a new intravenous anesthetic agent chemically unrelated to barbiturates or other intravenous anesthetic agents. It was found to produce rapid onset of anesthesia and early recovery similar to that obtained with
pentothal sodium. The purpose fo the present study is to compare the cardiovascular and respiratory effect of propofol with the cardiovascular and respiratory effect of pentothal sodium.
Sixty patients of ASA class 1 or 2 scheduled to undergo gynecological, orthopedic and abdominal procedures were classified randomly into 3 Groups. Group A were injected with pento thal sodium 5.0mg/kg and Group B, C received propofol 2.0mg/kg,
2.5mg/kg
respectively.
@ES The results were as follows;
@EN 1) Change of the systolic arterial pressure. Propofol 2.5mg/kg produced the greatest deerease in systolic blood pressure when compared with other groups.
2) Change of the heart rate. Change of the heart rate was minimal after both doses of propofol when compared with pentothal sodium.
3) Respiratory effect. Respiratory measurement in 20 unpremedicated surgical patients who received an induction dose of propofol 2.5mg/kg showed significant respiratory depression.
4) Side effect. Excitatory effects and pain on injection were more frequent in propofol group than pentotnal sodium group. Nausea, vomiting were more frequent in pentothal sodium group than propofol group.
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